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Cholesterol transport in the lysosome. Upon being delivered to the... |  Download Scientific Diagram
Cholesterol transport in the lysosome. Upon being delivered to the... | Download Scientific Diagram

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the  function of the C-terminal luminal domain in cholesterol transport | PNAS
3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport | PNAS

IJMS | Free Full-Text | Cholesterol Transport in Wild-Type NPC1 and P691S:  Molecular Dynamics Simulations Reveal Changes in Dynamical Behavior
IJMS | Free Full-Text | Cholesterol Transport in Wild-Type NPC1 and P691S: Molecular Dynamics Simulations Reveal Changes in Dynamical Behavior

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis  and Is a Targetable Pathway in Niemann-Pick Type C - ScienceDirect
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C - ScienceDirect

A working model of NPC1/NPC2-mediated LDL-derived cholesterol transport...  | Download Scientific Diagram
A working model of NPC1/NPC2-mediated LDL-derived cholesterol transport... | Download Scientific Diagram

The NPC1 protein: structure implies function - ScienceDirect
The NPC1 protein: structure implies function - ScienceDirect

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the  function of the C-terminal luminal domain in cholesterol transport | PNAS
3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport | PNAS

Correction of Niemann-Pick type C1 disease with the histone deacetylase  inhibitor valproic acid | bioRxiv
Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid | bioRxiv

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick  C1 | eLife
Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1 | eLife

Human NPC1: topology, structure, and function. (A) Predicted topology... |  Download Scientific Diagram
Human NPC1: topology, structure, and function. (A) Predicted topology... | Download Scientific Diagram

Signatures of natural selection and ethnic-specific prevalence of NPC1  pathogenic mutations contributing to obesity and Niemann–Pick disease type  C1 | Scientific Reports
Signatures of natural selection and ethnic-specific prevalence of NPC1 pathogenic mutations contributing to obesity and Niemann–Pick disease type C1 | Scientific Reports

Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein  confines dynamics of its N-terminal domain | PLOS Computational Biology
Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain | PLOS Computational Biology

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the  function of the C-terminal luminal domain in cholesterol transport | PNAS
3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport | PNAS

Structural basis for itraconazole-mediated NPC1 inhibition | Nature  Communications
Structural basis for itraconazole-mediated NPC1 inhibition | Nature Communications

NPC1 and PTCH1* SSD structural and surface comparison a, NPC1 SSD. The... |  Download Scientific Diagram
NPC1 and PTCH1* SSD structural and surface comparison a, NPC1 SSD. The... | Download Scientific Diagram

NPC1, intracellular cholesterol trafficking and atherosclerosis. | Semantic  Scholar
NPC1, intracellular cholesterol trafficking and atherosclerosis. | Semantic Scholar

Structural basis for itraconazole-mediated NPC1 inhibition | Nature  Communications
Structural basis for itraconazole-mediated NPC1 inhibition | Nature Communications

Role of the SSD within NPC1 in mediating the binding between NPC1... |  Download Scientific Diagram
Role of the SSD within NPC1 in mediating the binding between NPC1... | Download Scientific Diagram

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1  and NPC2 - ScienceDirect
Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2 - ScienceDirect

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the  function of the C-terminal luminal domain in cholesterol transport | PNAS
3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport | PNAS

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol  Transfer and Ebola Infection
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol  Transfer and Ebola Infection
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

JCM | Free Full-Text | Molecular Genetics of Niemann–Pick Type C Disease in  Italy: An Update on 105 Patients and Description of 18 NPC1 Novel Variants
JCM | Free Full-Text | Molecular Genetics of Niemann–Pick Type C Disease in Italy: An Update on 105 Patients and Description of 18 NPC1 Novel Variants

A working model of NPC1/NPC2-mediated LDL-derived cholesterol transport...  | Download Scientific Diagram
A working model of NPC1/NPC2-mediated LDL-derived cholesterol transport... | Download Scientific Diagram

JCM | Free Full-Text | Molecular Genetics of Niemann–Pick Type C Disease in  Italy: An Update on 105 Patients and Description of 18 NPC1 Novel Variants
JCM | Free Full-Text | Molecular Genetics of Niemann–Pick Type C Disease in Italy: An Update on 105 Patients and Description of 18 NPC1 Novel Variants

NPC1 structure and proposed pathway of cholesterol binding (A)... |  Download Scientific Diagram
NPC1 structure and proposed pathway of cholesterol binding (A)... | Download Scientific Diagram